Karen Mendelson kam2030@med.cornell.edu Department of Surgery Weill Cornell Medical College 1300 York Avenue Rm LC-711 New York, NY, 10065 phone (212) 746-9485 / fax (212) 746-7378

Co-mentorship with Timothy Hla, PhD
Department of Pathology
Weill Cornell Medical College
1300 York Avenue Rm A-607

Research

My research is focused on uncovering the role of sphingosine 1 phosphate signaling in a zebrafish model.

Education

PhD	Weill Cornell Graduate School of Medical Sciences	2010
MA	Boston University	2004
BA	Princeton University	2003

Publications

Mendelson K, Swendeman S, Saftig, P, and Blobel CP. Stimulation of the PDGFRI activates ADAM17 and promotes metalloproteinase-dependent crosstalk between the PDGFRI and EGFR signaling pathways. J. Biol. Chem. 2010;285:25024-25032.

Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, and Blobel CP. Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells, but not in pericytes. Circ Res. 2010;106:932-940.

Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S, Blobel CP. VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling. Circ Res. 2008;103:916-918.

Mettler BA, Sales VL, Stucken CL, Anttila V, Mendelson K, Bischoff J, Mayer JE Jr. Stem cell-derived, tissue-engineered pulmonary artery augmentation patches in vivo. Ann Thorac Surg. 2008;86:132-140.

Mendelson K., Aikawa E., Mettler B., Sales V., Martin D., Mayer J., Schoen F. Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovasc Pathol. 2007;16:277-282.

Mendelson K. and Schoen F. Heart Valve Tissue Engineering: Approaches, Progress, and Challenges. Annals of Biomedical Engineering. 2006;34:1799-1819.

Aikawa E., Whittaker P., Farber M., Mendelson K., Padera R., Aikawa M., Schoen F. Human Semilunar Cardiac Valve Remodeling by Activated Cells from Fetus to Adult: Implications for Postnatal Adaptation, Valve Pathology and Tissue Engineering. Circulation. 2006;113:1344-1352.

Wilson-Fritch L., Burkart A., Bell G., Mendelson K., et al. Mitochondrial Biogenesis and Remodeling During Adipogenesis and in Response to the Insulin Sensitizer Rosiglitazone. Molecular and Cellular Biology. 2003;23:1085-1094.