Susanna Liu sul2018@med.cornell.edu Department of Surgery Weill Cornell Medical College 1300 York Avenue Rm LC-711 New York, NY, 10065 phone (212) 746-9485 / fax (212) 746-7378

Research

In my project, the role of Smad5 in the regulation of hematopoietic development is being compared with that of Smad1. Previous studies using an inducible Smad1 ES cell line showed the importance of Smad1 in embryonic hematopoiesis. Zafonte et al. found that a 6-hour pulse of Smad1 overexpression specifically at day 2 of embryoid body (EB) development led to a 5-fold increase of blast colonies and subsequently hematopoietic derivatives, including primitive erythroid colonies. To compare the Smad1 studies, an inducible Smad5 ES cell line has been generated. Using this cell line, Smad5 expression will be induced during EB development at various time points. Its effect on hematopoietic development will be measured by counting primitive, definitive, and blast colonies.

Education

MS	Albert Einstein College of Medicine	2007
BS	Massachusetts Institute of Technology	2005

Publications

Polo JM, Liu S, Figuero ME, Kulalert W, Eminli S, Tan KY, et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010; 28: 848 - 855.

Zafonte, B. T., Liu, S., Lynch-Kattman, M., Torregroza, I., Benvenuto, L., Kennedy, M., Keller, G., and Evans, T. (2007). Smad1 Expands the Hemangioblast Population within a Limited Developmental Window. Blood. 109: 516-523.